On March 11, 1954, the protocol ceremony was held for the laying of the first stone for the construction of the new hospital, which would be established on a piece of land in Hato Rey that was acquired by La Liga. Dr. González Martínez was in delicate health and hospitalized for the second time, which was represented by the First Lady of the Country, Mrs. Inés Mendoza. Dr. González Martínez passed away on April 20, 1954, so Governor Luis Muñoz Marín proclaimed Dr. Isaac González Martínez Day every April 20 of each year.