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Dr. Gonzalez Martinez and his colleague, Dr. Pedro Malaret, join in crusade in the diagnosis and treatment of anemia typical of the tropical zone, research undertaken by the North American Dr. Bailey K. Ashford, together with a group of outstanding physicians. Ashford, together with a group of distinguished physicians, founded the Institute of Tropical Medicine and Hygiene, replacing the Anemia Commission.
He discovers on the island, the condition of "Canine Piroplasmosis", which is transmitted through the tick that also gives it to other animals. In the photo taken at Finca San Andres in Utuado appear the health leaders of the time who together made great contributions to the country, from left to right: Dr. Bailey K. Ashford, Founder of the Institute of Tropical Medicine; Dr. Bailey K. Ashford, Founder of the Institute of Tropical Medicine; Dr. Bailey K. Ashford, Founder of the Institute of Tropical Medicine. Ashford, Founder of the Institute of Tropical Medicine; Dr. Federico Trilla Aguiar, Surgeon; Dr. Pedro Malaret, Executive Secretary of the Anemia Commission; Dr. King, U.S. Navy; Dr. William F. Lippit, First Commissioner of Health, under the Jones Act; Dr. Isaac González Martínez, Co-Founder of the Institute; Dr. Pedro Gutiérrez Ygaravides, Co-Founder of the Institute; Dr. Ric. Mestre of Mayagüez.
An epidemic of bubonic plague occurred in Puerto Rico. His experience in Lisbon, Portugal allowed him to carry out his bacteriological diagnosis in 48 hours, eradicating it, a feat never before accomplished in the history of this disease. Founded with his great friend, Dr. Ramón Ruiz Arnau, the medical journal "Anales Médicos de Puerto Rico".
Presented the first case of "Ainhun" on the island at a meeting of doctors of the San Juan Municipal Beneficence. He was appointed Director of the Island Biological Laboratory.
Moved to the capital city of San Juan, was appointed Island Director of the Biology Laboratory at the island level and member of the Board of Medical Examiners.
The second Anemia Commission of Puerto Rico is officially founded. Dr. González Martínez's great contribution to the international medical world is recognized.
With Dr. Malaret, he established a dispensary for the diagnosis and treatment of the tropical anemia, "Uncinariasis", a research subject of Dr. Bailey K. Ashford.
The discovery of the "Intestinal Schistosotomiasis (Bilharzia)" in the American continent is officially confirmed. Together with Dr. Pedro Malaret, they create the Municipal Commission for the Study of "Uncinariasis and Bilharzia" in the city of Mayagϋez.
During his research work, he examined a stool sample from two young Mayagϋezan patients and found very different eggs. His interest led him to follow the clinical course of the patient and when they died, he performed an autopsy and found the eggs of the "Bilharzia" in the vessels of the intestine, with changes in the liver, as it is known in Puerto Rico. Bilharzia, later defined as Bilharziosis, was discovered in Europe by Theodor Ma ximilian Bilharz, who gave the genus its name. This disease is epidemic in Africa and was probably introduced in the island in the times of slavery with the blacks coming from Angola, Congo and Cafrería. In the medical report made by Dr. Isaac Gonzalez Martinez to the Medical Association of Puerto Rico, was the first description of the disease "intestinal Bilharziosis" in America, whose publication toured all medical libraries and researchers around the world. He was appointed as Special Commissioner for the clinical and bacteriological diagnosis of some cases of leprosy in Aguadilla and an epidemic of typhoid fever in Mayagϋez. In Arecibo he discovered the first case of a new species of "Distomatosis Hepatica" in a peasant.
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